Comparison therapy of Tocilizumab+ MTX vs Riruximab+MTX in treatment Essay

Comparison therapy of Tocilizumab+ MTX vs Riruximab+MTX in treatment of progressive rhuematoid arthritis - Essay Examplerature on two new agents, tocilizumab and rituximab was collected, and the reports examining the safety and efficacy of these two novel agents entirely or in combination with methotrexate in the treatment of active rheumatoid arthritis were reviewed through a qualitative methodology.Some trials have indicated positive effects of combination of tocilizumab and rituximab with methotrexate. Rituximab successfully causes depletion of B lymphocytes in indomitable cases of RA and may be a key component in the interruption of the disease pathogenesis. It is pass judgment that once data from clinical trials be available, tocilizumab will be used with the same goal of increase symptom-free period and preventing joint destruction. However, based on the results of the literature review, it can be stated that for a long therapy of active rheumatoid arthritis, rituximab a nd methotrexate combination is safer and more efficacious than tocilizumab and methotrexate combination, although more long-term trials are required for the later combination.As far as the facts from literature review are concerned, although the efficacy of some(prenominal) these regimens have been established based on standard criteria, and given this scenario, although rough semblance in different parameters of efficacy and safety can be made, a decisive conclusion is not possible without progress trial or research. Since there are different parameters of a clinically effective treatment, an identical comparison of both the regimens are needed, with the problem being selection of patients with identical baseline. A comparison is also necessary based on patients perception on the symptoms. A future trial involving these criteria may be needed to arrive at a guideline based on these regimens.Figure 6 Percentage of responders according to the American College of Rheumatology (AC R) improvement criteria and the Disease Activity Score in 28 joints (DAS28) as well as mean change in Modified Health Assessment